Rat Anti-IL4 Mouse Monoclonal Antibody [11B11]-PURE


Size

0,5 mg

Catalog no.

BD-MOIL4PU(V500)

Price

228 EUR

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Gene Name

IL4

Conjugate

PURE

Clone

11B11

French translation

anticorps

Concentration

500 µg/mL

Expiration

After 1 year

Application

Flow Cytometry Method

Remark

For Recherche Use Only.

Immunogen

Partially Purified Mouse IL-4

Latin name

Mus musculus,Rattus norvegicus

Storage

2-8°C, store in dark, do not freeze

Other Names of gene

Interleukin-4, IaIF, BSF-1, HCGF, MCGF-2, MFF, TCGF-2

Formulation

Aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3).

Properties

If you buy Antibodies supplied by Immunostep they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

Rat Anti-IL4 Mouse Monoclonal Antibody [11B11]-PURE is a mouse monoclonal antibody, specific for [11B11] clones, this reagent was conjugated with PURE format and reported for use in flow cytometric analysis to react with IL4 antigen in T and mast cells, also in biosophils, IL4 is a stimulant factor of growth and activation cells, it has also a role in regulation of development of T helper subsets.

Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The ultrapure Anti-IL4 Mouse Monoclonal Antibody [11B11]-PURE supplied from Immunostep is supplied in 1. The reagent contains very low traces of production synthesis impurities and is highly purified by ultra filtration and distillation for the chemical compounds.

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.

Gene

Interleukin 4 (IL4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. It is used for dendritic and T cell therapy. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13. Recombinant, GMP rec. E. coli interleukin-4 for cell culture supplied by GENTAUR. Free samples on request.